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Who is most susceptible to B12 deficiency ( 2 ): Those with digestive disorders such as IBD and gastric resections Use of Proton Pump Inhibitors (Prilosec) for more than 12 months Use of Histamine (H2) blockers to treat heartburn for more than 12 months Vegans or strict vegetarians Adults over 75 years old Four Reasons to Get B12 Injections: Healthy Pregnancy - You may know that folate is essential for a pregnant woman to prevent birth defects like spina bifida

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Acknowledgements We thank Elisabeth Rushing (Institute of Neuropathology, University Hospital Zurich) for support with the analysis of histological sections and Friedhelm Bladt and Frank Jhrling (Merck, Darmstadt, Germany) for providing EMD1214063 and for helpful discussions